Mirtazapine: Uses, side effects, warnings, and interactions

mirtazapine and alcohol

Mirtazapine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide..

  1. Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible.
  2. If you start to have problems with your weight while taking mirtazapine, talk to your doctor or pharmacist.
  3. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
  4. Alcohol has similar effects on these neurotransmitters, which can lead to an increase in feelings of depression, anxiety and irritability when mixed with mirtazapine.
  5. The risk seems to reduce after the age of 24 years, and people are more prone to these effects when they first start taking the drug.
  6. Statistical analyses were completed on an intent-to-treat study group.

Categorical baseline measures were compared by chi-square analysis, corrected for continuity. Statistical analyses were completed on an intent-to-treat study group. An alpha level of less than or equal to 0.05 was used in the study to indicate statistical significance. All analyses were conducted using the Statistical Package for the Social Sciences, version 15.0 [12]. Before entry into the acute phase treatment protocol, the study was explained, and written informed consent was obtained from all subjects after all procedures had been fully explained.

Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you’ve been taking mirtazapine for a long time. Doctors do not usually prescribe mirtazapine to children and teenagers because they are more likely to experience suicidal thoughts or actions as a side effect. If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. Before taking mirtazapine, a person should talk to their doctor about their history or family history of psychiatric disorders and suicidal thoughts or actions.

Drug Interactions

Our qualified team of professionals will be able to assess your condition and provide a treatment plan that will help you achieve long-term recovery. However, mixing the two substances can also cause a range of physical side effects such as nausea, vomiting, dizziness, insomnia and sexual dysfunction. In some cases, mirtazapine and alcohol blackouts and memory loss can also occur, both of which can put you at risk of accidents, potential crimes and other dangers.

mirtazapine and alcohol

However, these side effects are generally mild, and not everyone experiences them. A person should follow their prescribed dosing and not attempt to adjust their dosage on their own or purposefully skip doses. Continuous baseline measures were compared by paired, 2-tailed t tests for continuous variables.

This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 3 Mar 2024), Cerner Multum™ (updated 4 Mar 2024), ASHP (updated 10 Mar 2024) and others. If you notice any other effects, check with your healthcare professional.

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have alcoholic eyes any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Mirtazapine drug interactions

Participants were required to be outpatients between 18 and 55 years of age at baseline to be included in the study. At the baseline assessment, participants were evaluated for the DSM-IV diagnoses of alcohol dependence and major depressive disorder, using an instrument called the MINI International Neuropsychiatric Interview [6]. The MINI has demonstrated good reliability, validity, and clinical utility [7]. The comorbid presence of both current alcohol dependence and current major depressive disorder was required for inclusion in the treatment study.

Appropriate studies have not been performed on the relationship of age to the effects of mirtazapine in the pediatric population. Drug interactions can prevent the medication from working in the usual way, and they can lead to dangerous side effects. It is very important that your doctor check your progress at regular visits, to allow changes in your dose and help reduce any side effects. Ask your healthcare professional how you should dispose of any medicine you do not use.

Check with your doctor right away if you have black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, sore throat, sores, ulcers, or white spots on the lips or in the mouth. Swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

To help avoid these, a person should discuss all their medications, including both over the counter and prescription drugs, with their healthcare provider before starting mirtazapine. They should also make them aware of any vitamins or other supplements that they are taking. Those improvements (compared to baseline levels) persisted at the one-year follow-up assessment, as noted in Figure 1. Following completion of the baseline assessment, participants were treated using an open-label study design.

Lovieno et al., 2011 [4] also noted the complete lack of study data on a number of newer antidepressants such as mirtazapine for treating comorbid populations. Thus, to date, no medications have consistently demonstrated efficacy for treating the large population of persons with comorbid major depressive disorder and alcohol dependence. Therefore, comorbid major depression and alcohol dependence currently represent a considerable unmet treatment need. To date, pharmacotherapy trials of depressed alcoholics (MDD/AUD) have focused on SSRI medications, with disappointing results, so effective treatments for that comorbid population are lacking. Mirtazapine is an FDA-approved medication for treating MDD with a unique pharmacological profile whose efficacy may exceed that of SSRIs. Results from our recent open label study suggest robust acute phase efficacy for mirtazapine for decreasing both the depression and the drinking of that population.

Mayo Clinic Press

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking alpha-pyrrolidinopentiophenone wikipedia this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Mirtazapine is an antidepressant that doctors prescribe to treat depression. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Mirtazapine may cause drowsiness, trouble with thinking, or trouble with controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, and able to think well. Your doctor may need to check your weight on a regular basis while you are using this medicine.

The authors recently conducted a first open label study evaluating the acute phase efficacy of mirtazapine for treating both the depressive symptoms and the drinking of persons with comorbid AD/MDD. Previous studies involving mirtazapine had not assessed level of drinking as an outcome variable. Results from our recent open label study [5] suggest robust acute phase efficacy for mirtazapine for decreasing both the depression and the drinking alcohol use disorder of that population. However, to date, no studies have evaluated the longer-term efficacy of mirtazapine in that population. We now report findings from a first long-term (two-year) naturalistic follow-up evaluation involving subjects from the acute phase trial. We hypothesized that mirtazapine would demonstrate long-term within-group efficacy for decreasing both the depressive symptoms and level of alcohol use of our subjects.

How to get help for mirtazapine and alcohol addiction

Some people want to magnify the effects of alcohol and mirtazapine either to provide extra relief from the symptoms of mental health conditions or for recreational purposes. Taking the two substances together can lead to serious health risks, addiction and even death by overdose. If you are struggling with mirtazapine and alcohol addiction, Primrose Lodge offers effective treatment which can help you break free from this cycle.